An extensive family collection, the Vaux Family Papers center around the lives of George Vaux V (1721-1803), George Vaux VII (1779-1836), and George Vaux VIII (1832-1915), their business partners, siblings, wives, and children, and encompasses the extended Vaux family of Warders, Sansoms, Heads, Graffs, Morrises, Cressons, and Mayberrys. The collection includes correspondence, financial accounts, receipts, business records, journals, diaries, photographs, and legal documents.

The Welsh non-conformist minister Richard Price (1723-1791) was a moral philosopher and political and economic theorist whose ideas leant support to the American cause during the Revolution. Of broad and liberal mind, he was an integral member of the intellectual coterie surrounding William Petty, the Earl of Shelburne, and was a founding member of the Unitarian Church. Befitting a latitudinarian thinker, the range of Richard Price's correspondence is extremely broad, touching upon his rationalistic philosophy and dissenting theology, his political views on British politics, America and the American Revolution, the Constitutional settlement, the future of the United States, social reform, demography, prisons, and slavery. The ninety letters in the collection are arranged chronologically, with correspondents including Charles Chauncy (8 letters, 1772-1779), Benjamin Franklin (7 letters, 1775-1789), John Howard (11 letters and a biographical manuscript, 1770-1789), Thomas Jefferson (3 letters, 1785-1789), Benjamin Rush (8 letters, 1786-1790), and Edward Wigglesworth (3 letters, 1775-1786), as well as lesser known figures such as the reformer John Howard.

Letters (including some transcripts and photostats) from and to Vaughan from many American and British correspondents, including: Also personal correspondence and business papers of Benjamin, Charles, Petty, Samuel Sr., Samuel Jr., William, William Oliver, and Sarah Vaughan (2 boxes); lectures, mostly in shorthand (3 vols.); a large number of notes and memoranda on a wide variety of topics, such as agriculture, architecture, astronomy, diplomacy, diseases, dueling, electricity, hieroglyphs, internal improvements, medicine, meteorology, land, manufactures, politics, punctuation, religion, silk-manufacturing, stock-breeding, taxation, Unitarianism, Benjamin Franklin, John Locke, Napoleon I, Joseph Priestley, Bowdoin College, town of Hallowell, Maine; notes on the peace negotiations, 1782-1783; miscellaneous legal papers; genealogy of the Abbott-Vaughan families. For a personal account of the collection, see Mrs. Mary Vaughan Marvin, "The Benjamin Vaughan Papers," APS Proceedings 95 (1951): 246-249.

The Calendar of the Papers of Benjamin Franklin prepared by Isaac Minis Hays for the bicentennial of Franklin's birth in 1906 provides access to the largest portion of the Franklin Papers at the APS. The items were originally bound into volumes in roughly chronological order, with letters to Franklin preceding those from Franklin and at the end of the collection, Franklin's letters owned by the University of Pennsylvania. Each manuscript is still identified by Hays' reference numbers, which include a roman numeral refering to the original volume followed by an arabic number to identify the folio. The electronic version of the finding aid replicates Hays' calendar, including the introductory material and item-level descriptions. It has been updated to reflect corrections in the metadata, corrections of personal names, dates, and description.